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bioRxiv · 10.1101/2021.03.11.435002

Identifying regions in prefrontal cortex related to working memory improvement: a novel meta-analytic method using electric field modeling

Wischnewski, M.·Mantell, K. E.·Opitz, A.
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Abstract

Altering cortical activity using transcranial direct current stimulation (tDCS) has been shown to improve working memory (WM) performance. Due to large inter-experimental variability in the tDCS montage configuration and strength of induced electric fields, results have been mixed. Here, we present a novel meta-analytic method relating behavioral effect sizes to electric field strength to identify brain regions underlying largest tDCS-induced WM improvement. Simulations on 69 studies targeting left prefrontal cortex showed that tDCS electric field strength in lower dorsolateral prefrontal cortex (Brodmann area 45/47) relates most strongly to improved WM performance. This region explained 7.8% of variance, equaling a medium effect. A similar region was identified when correlating WM performance and electric field strength of right prefrontal tDCS studies (n = 18). Maximum electric field strength of five previously used tDCS configurations were outside of this location. We thus propose a new tDCS montage which maximizes the tDCS electric field strength in that brain region. Our findings can benefit future tDCS studies that aim to affect WM function. Highlights- We summarize the effect of 87 tDCS studies on working memory performance - We introduce a new meta-analytic method correlating tDCS electric fields and performance - tDCS-induced electric fields in lower DLPFC correlate significantly with improved working memory - The lower DLPFC was not maximally targeted by most tDCS montages and we provide an optimized montage

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Wischnewski, M., Mantell, K. E., Opitz, A.. 2021-03-11. Identifying regions in prefrontal cortex related to working memory improvement: a novel meta-analytic method using electric field modeling. https://doi.org/10.1101/2021.03.11.435002

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