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bioRxiv · 10.1101/2021.03.06.434206

Lag structure of BOLD signals within white matter in resting-state fMRI

Abstract

PurposePrevious studies have demonstrated that BOLD signals in gray matter in resting-state functional MRI (RSfMRI) have variable time lags, representing apparent propagations of fMRI BOLD signals in gray matter. We complemented existing findings and explored the corresponding variations of signal latencies in white matter. MethodsWe used data from the Brain Genomics Superstruct Project, consisting of 1412 subjects (both sexes included) and divided the dataset into ten equal groups to study both the patterns and reproducibility of latency estimates within white matter. We constructed latency matrices by computing cross-correlations between voxel pairs. We also applied a clustering analysis to identify functional networks within white matter, based on which latency analysis was also performed to investigate lead/lag relationship at network level. A dataset consisting of various sensory states (eyes closed, eyes open and eyes open with fixation) was also included to examine the relationship between latency structure and different states. ResultsProjections of voxel latencies from the latency matrices were highly correlated (average Pearson correlation coefficient = 0.89) across the subgroups, confirming the reproducibility and structure of signal lags in white matter. Analysis of latencies within and between networks revealed a similar pattern of inter- and intra-network communication to that reported for gray matter. Moreover, a dominant direction, from inferior to superior regions, of BOLD signal propagation was revealed by higher resolution clustering. The variations of lag structure within white matter are associated with different sensory states. ConclusionsThese findings provide additional insight into the character and roles of white matter BOLD signals in brain functions.

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BibTeXRIS

Guo, B., Zhou, F., Li, M., Gore, J. C.. 2021-03-08. Lag structure of BOLD signals within white matter in resting-state fMRI. https://doi.org/10.1101/2021.03.06.434206

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