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bioRxiv · 10.1101/2021.02.28.433226

Concurrent feature-specific reactivation within the hippocampus and neocortex facilitates episodic memory retrieval

Abstract

The hippocampus is a key brain region for the storage and retrieval of episodic memories, but how it performs this function is unresolved. According to the hippocampal indexing theory, the hippocampus stores an event-specific index of the pattern of neocortical activity that occurred during perception. During retrieval, reactivation of the index by a partial cue facilitates the reactivation of the associated neocortical pattern. Therefore, event-specific retrieval requires joint reactivation of the hippocampal index and the associated neocortical networks. To test this theory, we examine the relation between performance on a recognition memory task requiring retrieval of image-specific visual details and feature-specific reactivation within the hippocampus and neocortex. We show that trial-by-trial recognition accuracy correlates with neural reactivation of low-level features (e.g. luminosity and edges) within the posterior hippocampus and early visual cortex for participants with high recognition lure accuracy. As predicted, the two regions interact, such that recognition accuracy correlates with hippocampal reactivation only when reactivation co-occurs within the early visual cortex (and vice-versa). In addition to supporting the hippocampal indexing theory, our findings show large individual differences in the features underlying visual memory and suggest that the anterior and posterior hippocampus represents gist-like and detailed features, respectively.

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BibTeXRIS

Bone, M. B., Buchsbaum, B. R.. 2021-02-28. Concurrent feature-specific reactivation within the hippocampus and neocortex facilitates episodic memory retrieval. https://doi.org/10.1101/2021.02.28.433226

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