RELATIONSHIP BETWEEN PARENTAL AGE AND SEVERITY OF OROFACIAL CLEFTS

Adamson, O. O.; Oladugba, A.; Alade, A.; Awotoye, W.; Busch, T.; Li, M.; Fashina, A.; Olotu, J.; Sule, V.; James, O.; Ogunlewe, M.; Adeyemo, W.; Butali, A.

doi:10.1101/2021.02.22.432246

bioRxiv · 10.1101/2021.02.22.432246

RELATIONSHIP BETWEEN PARENTAL AGE AND SEVERITY OF OROFACIAL CLEFTS

Adamson, O. O.·Oladugba, A.·Alade, A.·Awotoye, W.·Busch, T.·Li, M.·Fashina, A.·Olotu, J.·Sule, V.·James, O.·Ogunlewe, M.·Adeyemo, W.·Butali, A.

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Abstract

OBJECTIVESThis study aims to investigate the relationship between paternal age, maternal age, and both on the severity of orofacial clefts. DESIGNThis was a retrospective study of cases which were subjects clinically diagnosed with non-syndromic cleft lip and/or palate (CL/P). Data was obtained from the AFRICRAN project database on Nigerian non-syndromic orofacial cleft cases. SETTINGThe samples for cases in this study were obtained at the Cleft clinic of Oral and Maxillofacial surgery at the Lagos University Teaching Hospital, Lagos. OUTCOMEPrimary outcome measure is severity of orofacial clefts and secondary outcome measure is to evaluate the effect of parental age in determining the incidence of left or right sided orofacial clefts. RESULTSThere is no statistical significant association between type of CL {+/-} P and parental age in young fathers (p=0.93). When old fathers are considered, percentage of complete (more severe) CL {+/-} P cases increases especially in old mothers and this was statistically significant (p=0.036). In old fathers, the risk of CL {+/-} P is increased (OR: 2.66, CI: 1.04-6.80) and also there is increased risk of developing right sided CL {+/-} P (OR: 1.61, CI: 1.0-2.59). There is reduced risk of isolated cleft palate in young fathers (OR: 0.36, CI: 0.07-1.71) but the risk increases when considering complete types (more severe) of isolated cleft palates (OR: 1.63, CI: 0.71-3.7) CONCLUSIONThe study shows a higher risk of CL {+/-} P is associated with increase fathers age.

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Adamson, O. O., Oladugba, A., Alade, A., Awotoye, W., Busch, T., Li, M., Fashina, A., Olotu, J., Sule, V., James, O., Ogunlewe, M., Adeyemo, W., Butali, A.. 2021-02-22. RELATIONSHIP BETWEEN PARENTAL AGE AND SEVERITY OF OROFACIAL CLEFTS. https://doi.org/10.1101/2021.02.22.432246

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