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bioRxiv · 10.1101/2021.02.17.431452

Dynamic predictive coding across the left fronto-temporal language hierarchy: Evidence from MEG, EEG and fMRI

Wang, L.·Schoot, L.·Brothers, T.·Alexander, E.·Warnke, L.·Kim, M.·Khan, S.·Hamalainen, M.·Kuperberg, G.
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Abstract

We used MEG and ERPs to track the time-course and localization of evoked activity produced by expected, unexpected plausible and implausible words during incremental language comprehension. We interpret the full pattern of evoked responses and functional connectivity within a hierarchical predictive coding framework in which evoked activity reflects residual information (error) that is passed up and down the cortical hierarchy. Between 300-500ms, the three conditions produced progressively larger responses within left temporal cortex (lexico-semantic prediction error), while implausible inputs produced a selectively enhanced response within left inferior frontal cortex (event-level prediction error). Between 600-1000ms, unexpected plausible words activated left inferior frontal and middle temporal cortices (feedback activity that induced top-down shifts of event-level and lexico-semantic representations), while highly implausible inputs activated posterior fusiform and medial temporal cortices, supporting orthographic reanalysis and new learning. Therefore, predictive coding may provide a unifying theory that links language comprehension to other domains of cognition.

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Wang, L., Schoot, L., Brothers, T., Alexander, E., Warnke, L., Kim, M., Khan, S., Hamalainen, M., Kuperberg, G.. 2021-02-17. Dynamic predictive coding across the left fronto-temporal language hierarchy: Evidence from MEG, EEG and fMRI. https://doi.org/10.1101/2021.02.17.431452

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