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bioRxiv · 10.1101/2021.02.16.431493

Polymorphism of Genetic Ambigrams

Dudas, G.·Huber, G.·Wilkinson, M.·Yllanes, D.
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Abstract

Double synonyms in the genetic code can be used as a tool to test competing hypotheses regarding ambigrammatic narnavirus genomes. Applying the analysis to recent observations of Culex narnavirus 1 and Zhejiang mosquito virus 3 ambigrammatic viruses indicates that the open reading frame on the complementary strand of the segment coding for RNA-dependent RNA polymerase does not code for a functional protein. Culex narnavirus 1 has been shown to possess a second segment, also ambigrammatic, termed Robin. We find a comparable segment for Zhejiang mosquito virus 3, a moderately diverged relative of Culex narnavirus 1. Our analysis of Robin polymorphisms suggests that its reverse open reading frame also does not code for a functional protein. We make a hypothesis about its role.

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Dudas, G., Huber, G., Wilkinson, M., Yllanes, D.. 2021-02-17. Polymorphism of Genetic Ambigrams. https://doi.org/10.1101/2021.02.16.431493

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