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bioRxiv · 10.1101/2021.02.14.431141

Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli

Bartoszek, E. M.·Jetti, S. K.·Chau, K. T. P.·Yaksi, E.
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Abstract

Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brains internal states.

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Bartoszek, E. M., Jetti, S. K., Chau, K. T. P., Yaksi, E.. 2021-02-16. Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli. https://doi.org/10.1101/2021.02.14.431141

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