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bioRxiv · 10.1101/2021.02.12.430921

Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans

Cho, H.·Schalk, G.·Adamek, M.·Moheimanian, L.·Coon, W. G.·Jun, S. C.·Wolpaw, J. R.·Brunner, P.
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Abstract

The scientific and clinical value of event-related potentials (ERPs) depends on understanding the contributions to them of three possible mechanisms: (1) additivity of time-locked voltage changes; (2) phase resetting of ongoing oscillations; (3) asymmetrical oscillatory activity. Their relative contributions are currently uncertain. This study uses analysis of human electrocorticographic activity to quantify the origins of movement-related potentials (MRPs) and auditory evoked potentials (AEPs). The results show that MRPs are generated primarily by endogenous additivity (88%). In contrast, P1 and N1 components of AEPs are generated almost entirely by exogenous phase reset (93%). Oscillatory asymmetry contributes very little. By clarifying ERP mechanisms, these results enable creation of ERP models; and they enhance the value of ERPs for understanding the genesis of normal and abnormal auditory or sensorimotor behaviors.

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Cho, H., Schalk, G., Adamek, M., Moheimanian, L., Coon, W. G., Jun, S. C., Wolpaw, J. R., Brunner, P.. 2021-02-16. Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans. https://doi.org/10.1101/2021.02.12.430921

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