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bioRxiv · 10.1101/2021.02.05.429902

Multiple dimensions underlying the functional organisation of the language network

Abstract

Understanding the different neural networks that support human language is an ongoing challenge for cognitive neuroscience. Which divisions are capable of distinguishing the functional significance of regions across the language network? A key separation between semantic cognition and phonological processing was highlighted in early meta-analyses, yet these seminal works did not formally test this proposition. Moreover, organisation by domain is not the only possibility. Regions may be organised by the type of process performed, as in the separation between representation and control processes proposed within the Controlled Semantic Cognition framework. The importance of these factors was assessed in a series of activation likelihood estimation meta-analyses that investigated which regions of the language network are consistently recruited for semantic and phonological domains, and for representation and control processes. Whilst semantic and phonological processing consistently recruit many overlapping regions, they can be dissociated (by differential involvement of bilateral anterior temporal lobes and superior temporal gyri) only when using both formal analysis methods and sufficient data. Both semantic and phonological regions are further dissociable into control and representation regions, highlighting this as an additional, distinct dimension on which the language network is functionally organised. Furthermore, some of these control regions overlap with multiple-demand network regions critical for control beyond the language domain, suggesting the relative level of domain-specificity is also informative. Multiple, distinct dimensions are critical to understand the role of language regions. Here we present a proposal as to the core principles underpinning the functional organisation of the language network. SIGNIFICANCE STATEMENTTraditional theories of the organisation of the cortical language network separate areas based on the type of information processed, such as distinct regions representing the meaning of words or their sounds. Here, we re-analyse and update a seminal study, to directly compare these networks. This differentiates some language regions, yet a high degree of overlap is found, suggesting this division alone, does not provide a full mapping of the language network. Additional dimensions, reflecting different kinds of information, are demonstrated to underlie the functional organisation of the language network. First, representation and control processes engage distinct regions in each subdomain. Secondly, comparison outside of language highlights the importance of a domain-specificity dimension, distinguishing subdomain-specific semantic control and domain-general control regions.

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BibTeXRIS

Hodgson, V. J., Lambon Ralph, M., Jackson, R. L.. 2021-02-05. Multiple dimensions underlying the functional organisation of the language network. https://doi.org/10.1101/2021.02.05.429902

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