Pharmacokinetics of Orally Administered GS-441524 in Dogs

Yan, V. C.; Khadka, S.; Arthur, K.; Ackroyd, J. J.; Georgiou, D. K.; Muller, F. L.

doi:10.1101/2021.02.04.429674

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bioRxiv · 10.1101/2021.02.04.429674

Pharmacokinetics of Orally Administered GS-441524 in Dogs

Yan, V. C.·Khadka, S.·Arthur, K.·Ackroyd, J. J.·Georgiou, D. K.·Muller, F. L.

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Abstract

Despite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury(R)) remains contentious. We previously pointed out pharmacokinetic, pharmacodynamic and toxicology reasons for why its parent nucleoside GS-441524, is better suited for COVID-19 treatment. Here, we assess the oral bioavailability of GS-441524 in beagle dogs and show that plasma concentrations [~]24-fold higher than the EC50 against SARS-CoV-2 are easily and safely sustained. These data support translation of GS-441524 as an oral agent for COVID-19.

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Yan, V. C., Khadka, S., Arthur, K., Ackroyd, J. J., Georgiou, D. K., Muller, F. L.. 2021-02-05. Pharmacokinetics of Orally Administered GS-441524 in Dogs. https://doi.org/10.1101/2021.02.04.429674

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