Metabolic control of type 2 innate lymphoid cells plasticity toward protective type 1-like cells during Mycobacterium tuberculosis infection

Hudrisier, D.; Corral, D.; Charton, A.; Krauss, M. Z.; Blanquart, E.; Levillain, F.; Lefrancais, E.; Girard, J.-P.; Eberl, G.; Poquet, Y.; Guery, J.-C.; Arguello, R. J.; Hepworth, M. R.; Neyrolles, O.

doi:10.1101/2021.01.19.427257

bioRxiv · 10.1101/2021.01.19.427257

Metabolic control of type 2 innate lymphoid cells plasticity toward protective type 1-like cells during Mycobacterium tuberculosis infection

Hudrisier, D.·Corral, D.·Charton, A.·Krauss, M. Z.·Blanquart, E.·Levillain, F.·Lefrancais, E.·Girard, J.-P.·Eberl, G.·Poquet, Y.·Guery, J.-C.·Arguello, R. J.·Hepworth, M. R.·Neyrolles, O.

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Abstract

Tissue-resident innate lymphoid cells (ILCs) regulate tissue homeostasis, protect against pathogens at mucosal surfaces and are key players at the interface of innate and adaptive immunity. How ILCs adapt their phenotype and function to environmental cues within tissues remains to be fully understood. Here, we show that Mycobacterium tuberculosis infection alters the phenotype and function of immature lung ILC2 toward a protective interferon-{gamma}-producing ILC1-like population. This differentiation is controlled by type 1 cytokines and is associated with a glycolytic program involving the transcription factor HIF1. Collectively, our data reveal how tissue-resident ILCs adapt to type 1 inflammation toward a pathogen tailored immune response.

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Hudrisier, D., Corral, D., Charton, A., Krauss, M. Z., Blanquart, E., Levillain, F., Lefrancais, E., Girard, J.-P., Eberl, G., Poquet, Y., Guery, J.-C., Arguello, R. J., Hepworth, M. R., Neyrolles, O.. 2021-01-19. Metabolic control of type 2 innate lymphoid cells plasticity toward protective type 1-like cells during Mycobacterium tuberculosis infection. https://doi.org/10.1101/2021.01.19.427257

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