Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

Wang, X.; Allen, M.; Reddy, J. S.; Carrasquillo, M. M.; Asmann, Y. W.; Funk, C.; Nguyen, T. T.; Malphrus, K. G.; Younkin, S. G.; Dickson, D. W.; Price, N.; Golde, T. E.; Ertekin-Taner, N.

doi:10.1101/2021.01.18.426999

bioRxiv · 10.1101/2021.01.18.426999

Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

Wang, X.·Allen, M.·Reddy, J. S.·Carrasquillo, M. M.·Asmann, Y. W.·Funk, C.·Nguyen, T. T.·Malphrus, K. G.·Younkin, S. G.·Dickson, D. W.·Price, N.·Golde, T. E.·Ertekin-Taner, N.

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Abstract

We identify a striking correlation in the directionality and magnitude of gene expression changes in brain transcriptomes between Alzheimers disease (AD) and Progressive Supranuclear Palsy (PSP). Further, the transcriptome architecture in AD and PSP is highly conserved between the temporal and cerebellar cortices, indicating highly similar transcriptional changes occur in pathologically affected and "unaffected" areas of the brain. These data have broad implications for interpreting transcriptomic data in neurodegenerative disorders.

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Wang, X., Allen, M., Reddy, J. S., Carrasquillo, M. M., Asmann, Y. W., Funk, C., Nguyen, T. T., Malphrus, K. G., Younkin, S. G., Dickson, D. W., Price, N., Golde, T. E., Ertekin-Taner, N.. 2021-01-20. Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions. https://doi.org/10.1101/2021.01.18.426999

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