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bioRxiv · 10.1101/2021.01.08.425863

Family cluster comparisons to detect infection by Mycobacterium leprae in at-risk populations of six endemic regions in Colombia.

Cardona-Castro, N.·Serrano-Coll, H.·Osorio-Leal, Y.·Escobar-Builes, M. V.
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Abstract

IntroductionLeprosy is a chronic infectious disease, caused by Mycobacterium leprae, which is endemic in some tropical countries. It is necessary to implement strategies for its detection and elimination. We propose a strategy useful could be identifying risk factors associated with a seropositive test in leprosy. ObjectiveWe aimed to quantify the infection rates and identify risk factors for M. leprae infection using the serological evaluations against NDO-LID in family clusters of leprosy patients, from regions with a high burden of leprosy in Colombia. ResultsWe observed that belong to a low socioeconomic condition (OR 5.6 [95% IC 1.1-29]) and living in geographic area of residing such as Choco and Atlantico (OR 2 [95% IC 1.1-3.7]) could be risk factors related to infection by M. leprae between the members of a family cluster. ConclusionsLeprosy is a persistent disease that affects vulnerable and large family clusters, in which the detection of antibodies against NDO-LID can be a useful tool for early detection of M. leprae in family clusters with high risk for this infection.

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Cardona-Castro, N., Serrano-Coll, H., Osorio-Leal, Y., Escobar-Builes, M. V.. 2021-01-08. Family cluster comparisons to detect infection by Mycobacterium leprae in at-risk populations of six endemic regions in Colombia.. https://doi.org/10.1101/2021.01.08.425863

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