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bioRxiv · 10.1101/2020.12.25.424420

AIE-nanoparticle assisted ultra-deep microscopy in the in vivo mouse brain under 1300-nm excitation

Li, D.·Zhang, H.·streich, L. L.·Lu, P.·Wang, L.·Prevedel, R.·Qian, J.
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Abstract

Aggregation-induced emission nanoparticles serve as promising fluorescence probes for multi-photon excitation microscopy due to the large absorption cross-section at NIR-IIb region. Here we present organic AIE nanoparticles that feature high aborption cross-section under three-photon excitation. We show that these enable ultra-deep NIR-IIa excited three-photon imaging in the in-vivo mouse brain.

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Li, D., Zhang, H., streich, L. L., Lu, P., Wang, L., Prevedel, R., Qian, J.. 2020-12-26. AIE-nanoparticle assisted ultra-deep microscopy in the in vivo mouse brain under 1300-nm excitation. https://doi.org/10.1101/2020.12.25.424420

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