Genomic and phylogenetic analyses of SARS-CoV-2 strains isolated in the city of Gwangju, South Korea

Min Ji, K.; Ji-eun, L.; Jae Keun, C.; Tae sun, K.; Jungwook, P.; Mi hyeon, L.; Da jeong, H.; Jin, J.; Ji-eun, Y.; Hye young, K.; Jin jong, S.; Kwang gon, K.

doi:10.1101/2020.12.16.423178

bioRxiv · 10.1101/2020.12.16.423178

Genomic and phylogenetic analyses of SARS-CoV-2 strains isolated in the city of Gwangju, South Korea

Min Ji, K.·Ji-eun, L.·Jae Keun, C.·Tae sun, K.·Jungwook, P.·Mi hyeon, L.·Da jeong, H.·Jin, J.·Ji-eun, Y.·Hye young, K.·Jin jong, S.·Kwang gon, K.

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Abstract

Since the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in late December 2019, the coronavirus disease 2019 (COVID-19) has spread fast around the world. RNA viruses, including SARS-CoV-2, have higher gene mutations than DNA viruses during virus replication. Variations in SARS-CoV-2 genome could contribute to efficiency of viral spread and severity of COVID-19. In this study, we analyzed the locations of genomic mutations to investigate the genetic diversity among isolates of SARS-CoV-2 in Gwangju. We detected non-synonymous and frameshift mutations in various parts of SARS-CoV-2 genome. The phylogenetic analysis for whole genome showed that SARS-CoV-2 genomes in Gwangju isolates are clustered within clade V and G. Our findings not only provide a glimpse into changes of prevalent virus clades in Gwangju, South Korea, but also support genomic surveillance of SARS-CoV-2 to aid in the development of efficient therapeutic antibodies and vaccines against COVID-19.

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Min Ji, K., Ji-eun, L., Jae Keun, C., Tae sun, K., Jungwook, P., Mi hyeon, L., Da jeong, H., Jin, J., Ji-eun, Y., Hye young, K., Jin jong, S., Kwang gon, K.. 2020-12-18. Genomic and phylogenetic analyses of SARS-CoV-2 strains isolated in the city of Gwangju, South Korea. https://doi.org/10.1101/2020.12.16.423178

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