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bioRxiv · 10.1101/2020.12.10.419861

The Laplacian eigenmaps dimensionality reduction of fMRI data for discovering stimulus-induced changes in the resting-state brain activity

Abstract

The resting brain at wakefulness is active even in the absence of goal-directed behavior or salient stimuli. However, patterns of this resting-state (RS) activity can undergo alterations following exposure to meaningful stimuli. This study aimed to develop an unbiased method to detect such changes in the RS activity after exposure to emotionally meaningful stimuli. For this purpose, we used functional magnetic resonance imaging (fMRI) of RS brain activity before and after the acquisition and extinction of experimental conditioned fear. A group of healthy volunteers participated in three fMRI sessions: a RS before fear conditioning, a fear extinction session, and a RS immediately after fear extinction. The fear-conditioning paradigm consisted of three neutral visual stimuli paired with a partial reinforcement by a mild electric current. We used both linear and non-linear dimensionality reduction approaches to distinguish between the initial RS and the RS after stimuli exposure. The principal component analysis (PCA) as a linear dimensionality reduction method did not differentiate these states. Using the non-linear Laplacian eigenmaps manifold learning method, we were able to show significant differences between the two RSs at the level of individual participants. This detection was further improved by smoothing the BOLD signal with the wavelet multiresolution analysis. The developed method can improve the discrimination of functional states collected in longitudinal fMRI studies.

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BibTeXRIS

Pospelov, N., Tetereva, A., Martynova, O., Anokhin, K.. 2020-12-11. The Laplacian eigenmaps dimensionality reduction of fMRI data for discovering stimulus-induced changes in the resting-state brain activity. https://doi.org/10.1101/2020.12.10.419861

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