Cross-Platform Omics Prediction procedure enables precision medicine in patients with stage-III melanoma

Wang, K. Y.; Pupo, G. M.; Tembe, V.; Patrick, E.; Strbenac, D.; Schramm, S.-J.; Thompson, J. F.; Scolyer, R. A.; Mueller, S.; Tarr, G.; Mann, G. J.; Yang, J. Y.

doi:10.1101/2020.12.09.415927

bioRxiv · 10.1101/2020.12.09.415927

Cross-Platform Omics Prediction procedure enables precision medicine in patients with stage-III melanoma

Wang, K. Y.·Pupo, G. M.·Tembe, V.·Patrick, E.·Strbenac, D.·Schramm, S.-J.·Thompson, J. F.·Scolyer, R. A.·Mueller, S.·Tarr, G.·Mann, G. J.·Yang, J. Y.

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Abstract

There is no consensus methodology that can account for the variation in omics signatures when they are acquired across different platforms and times. This poses a significant barrier to the implementation of valuable biomarkers into clinical practice. We present a novel procedure (Cross-Platform Omics Prediction) that accounts for these variations and demonstrate its utility in three risk models for different diseases that is suitable for prospective and multi-centre clinical implementation.

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Wang, K. Y., Pupo, G. M., Tembe, V., Patrick, E., Strbenac, D., Schramm, S.-J., Thompson, J. F., Scolyer, R. A., Mueller, S., Tarr, G., Mann, G. J., Yang, J. Y.. 2020-12-09. Cross-Platform Omics Prediction procedure enables precision medicine in patients with stage-III melanoma. https://doi.org/10.1101/2020.12.09.415927

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