Decision value signals in the ventromedial prefrontal cortex and anhedonia across mood and psychotic disorders

Kang, M. S.; Wolf, D.; Kazinka, R.; Lee, S.; Ruparel, K.; Elliott, M.; Baldassano, C.; Xu, A.; Cieslak, M.; Prettyman, G.; Satterthwaite, T.; Kable, J.

doi:10.1101/2020.12.01.407197

bioRxiv · 10.1101/2020.12.01.407197

Decision value signals in the ventromedial prefrontal cortex and anhedonia across mood and psychotic disorders

Kang, M. S.·Wolf, D.·Kazinka, R.·Lee, S.·Ruparel, K.·Elliott, M.·Baldassano, C.·Xu, A.·Cieslak, M.·Prettyman, G.·Satterthwaite, T.·Kable, J.

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Abstract

Deficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for a shared transdiagnostic mechanism underlying impairments in motivation and pleasure across major depression, bipolar disorder, and schizophrenia. We found that value signals in the ventromedial prefrontal cortex (vmPFC) during decision-making were dampened in individuals with greater motivational and hedonic deficits, regardless of the primary diagnosis. This relationship remained significant while controlling for diagnosis-specific symptoms of mood and psychosis, such as depression as well as positive and negative symptoms. Our results demonstrate that dysfunction in the vmPFC during value-based decision-making is specifically linked to motivational and hedonic impairments across various psychiatric conditions. These findings provide a quantitative neural target for the potential development of novel treatments for amotivation and anhedonia.

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Kang, M. S., Wolf, D., Kazinka, R., Lee, S., Ruparel, K., Elliott, M., Baldassano, C., Xu, A., Cieslak, M., Prettyman, G., Satterthwaite, T., Kable, J.. 2020-12-02. Decision value signals in the ventromedial prefrontal cortex and anhedonia across mood and psychotic disorders. https://doi.org/10.1101/2020.12.01.407197

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