MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

Esslinger, C.; Schmitt, S.; Weber, M.; Hillenbrand, M.; Seidenberg, J.; Zingg, A.; Townsend, C.; Eicher, B.; Rutkauskaite, J.; Riese, P.; Guzman, C. A.; Fischer, K.

doi:10.1101/2020.12.01.406934

bioRxiv · 10.1101/2020.12.01.406934

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

Esslinger, C.·Schmitt, S.·Weber, M.·Hillenbrand, M.·Seidenberg, J.·Zingg, A.·Townsend, C.·Eicher, B.·Rutkauskaite, J.·Riese, P.·Guzman, C. A.·Fischer, K.

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Abstract

Fast track microfluidic screening of the antibody repertoires of 12 convalescent COVID-19 donors comprising 2.8mio antibodies yielded MTX-COVAB, a human-derived monoclonal antibody with low picomolar neutralization IC50 of SARS-CoV-2. COVAB neutralization potency is on par with the Regeneron cocktail as demonstrated in a comparative neutralization assay. MTX-COVAB shows strong efficacy in vivo and binds to all currently identified clinically relevant variants of SARS-CoV-2. MTX-COVAB completes GMP manufacturing by the end of this year and will be tested in the clinic in March 2021.

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Esslinger, C., Schmitt, S., Weber, M., Hillenbrand, M., Seidenberg, J., Zingg, A., Townsend, C., Eicher, B., Rutkauskaite, J., Riese, P., Guzman, C. A., Fischer, K.. 2020-12-02. MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19. https://doi.org/10.1101/2020.12.01.406934

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