Whole Genome Sequence Analysis of Shigella from Malawi Identifies Fluoroquinolone Resistance

Stenhouse, G. E.; Jere, K. C.; Peno, C.; Bengtsson, R. J.; Chinyama, E.; Mandolo, J.; Cain, A. K.; Iturriza_Gomara, M.; Bar-Zeev, N.; Cunliffe, N. A.; Cornick, J.; Baker, K. S.

doi:10.1101/2020.11.20.391235

bioRxiv · 10.1101/2020.11.20.391235

Whole Genome Sequence Analysis of Shigella from Malawi Identifies Fluoroquinolone Resistance

Stenhouse, G. E.·Jere, K. C.·Peno, C.·Bengtsson, R. J.·Chinyama, E.·Mandolo, J.·Cain, A. K.·Iturriza_Gomara, M.·Bar-Zeev, N.·Cunliffe, N. A.·Cornick, J.·Baker, K. S.

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Abstract

Increasing antimicrobial resistance and limited alternative treatments led to fluoroquinolone resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterised multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.

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Stenhouse, G. E., Jere, K. C., Peno, C., Bengtsson, R. J., Chinyama, E., Mandolo, J., Cain, A. K., Iturriza_Gomara, M., Bar-Zeev, N., Cunliffe, N. A., Cornick, J., Baker, K. S.. 2020-11-20. Whole Genome Sequence Analysis of Shigella from Malawi Identifies Fluoroquinolone Resistance. https://doi.org/10.1101/2020.11.20.391235

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