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bioRxiv · 10.1101/2020.11.20.391128

A putative erm gene is present in ΔermB Clostridioides difficile isolates showing high levels of resistance to clindamycin

Ramirez Hernandez, V.·Ramirez Vargas, G.
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Abstract

Clostridioides difficile has become the leading cause of hospital-acquired diarrhea. Clindamycin is a member of the macrolide-lincosamide-streptogramin B family of protein synthesis inhibitors. Been the ribosomal methylation the most widespread mechanism of resistance to these antibiotics in C difficile erm genes usually produce high levels of resistance to these drugs. In this short report we present evidence about the presence of an unreported putative erm gene in C difficile isolates that despite of presenting a {Delta}ermB genotype maintain high levels of clindamycin resistance.

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Ramirez Hernandez, V., Ramirez Vargas, G.. 2020-11-20. A putative erm gene is present in ΔermB Clostridioides difficile isolates showing high levels of resistance to clindamycin. https://doi.org/10.1101/2020.11.20.391128

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