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bioRxiv · 10.1101/2020.11.18.386128

Enhanced odour-associated memory performance with a Y-maze assembly in Drosophila

Abstract

The neural basis of behaviour is identified by systematically disrupting the activity of specific neurons and screening for loss in phenotype. Robust, high-scoring behavioural assays are thus necessary for identifying the neural circuits of novel behaviours. Here, we report the design and use of a Y-maze based classical olfactory learning and memory assay in Drosophila. Appetitive memory scores in our Y-mazes are considerably better and longer-lasting than that from a commonly used T-maze design. We found that the mechanism that traps flies in their choice of an odour is mainly responsible for the improving scores in the Y-mazes. Using Y-mazes, we could assay significant 24 h gustatory aversive memories in flies. These aversive memories are susceptible to protein synthesis inhibitor cycloheximide (CXM) and therefore embodies long-term memory (LTM). When anaesthesia resistant memory (ARM) deficient radish mutant flies are trained with dry sucrose, 24 h memory is severely disrupted. However, when we trained with 2 M sucrose-agar and tested in Y-mazes, radish mutants exhibited a residual 24 appetitive memory. This memory is not ARM, and we show that it is not CXM sensitive LTM either. It could be a third form of appetitive consolidated memory in flies. The Y-maze assembly described here is particularly sensitive and will thus enable the study of new memory phenotypes in Drosophila.

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BibTeXRIS

Mohandasan, R., Iqbal, F. M., Thakare, M. R., Sridharan, M., Das, G.. 2020-11-20. Enhanced odour-associated memory performance with a Y-maze assembly in Drosophila. https://doi.org/10.1101/2020.11.18.386128

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