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bioRxiv · 10.1101/2020.11.06.367961

Efficacy of broflanilide (VECTRON T500), a new meta-diamide insecticide, for indoor residual spraying against pyrethroid-resistant malaria vectors.

Ngufor, C.·Govoetchan, R.·Fongnikin, A.·Vigninou, E.·Syme, T.·Akogbeto, M.·Rowland, M.
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Abstract

The rotational use of insecticides with different modes of action for indoor residual spraying (IRS) is recommended for improving malaria vector control and managing insecticide resistance. A more diversified portfolio of IRS insecticides is required; insecticides with new chemistries which can provide improved and prolonged control of insecticide-resistant vector populations are urgently needed. Broflanilide is a newly discovered insecticide being considered for malaria vector control. We investigated the efficacy of a wettable powder (WP) formulation of broflanilide (VECTRON T500) for IRS on mud and cement wall substrates in WHO laboratory and experimental hut studies against pyrethroid-resistant malaria vectors in Benin, in comparison with pirimiphos-methyl CS (Actellic(R) 300CS). There was no evidence of cross-resistance to pyrethroids and broflanilide in CDC bottle bioassays. In laboratory cone bioassays, mortality of susceptible and pyrethroid-resistant A. gambiae s.l. with broflanilide WP treated substrates was >80% for 6-14 months. At application rates of 100mg/m2 and 150 mg/m2, mortality of wild pyrethroid-resistant A. gambiae s.l. entering treated experimental huts in Cove, Benin was 57%-66% with broflanilide WP and did not differ significantly from pirimiphos-methyl CS (57-66% vs. 56%, P>0.05). Mosquito mortality did not differ between the two application rates and local wall substrate-types tested (P>0.05). Throughout the 6-month hut trial, monthly wall cone bioassay mortality on broflanilide WP treated hut walls remained >80% for both susceptible and resistant strains of A. gambiae s.l.. Broflanilide shows potential to significantly improve the control of malaria transmitted by pyrethroid-resistant mosquito vectors and would thus be a crucial addition to the current portfolio of IRS insecticides. One Sentence SummaryVECTRON T500, a new wettable powder formulation of broflanilide developed for indoor residual spraying, showed high and prolonged activity against wild pyrethroid-resistant malaria vectors, on local wall substrates, in laboratory bioassays and experimental household settings in Benin.

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Ngufor, C., Govoetchan, R., Fongnikin, A., Vigninou, E., Syme, T., Akogbeto, M., Rowland, M.. 2020-11-08. Efficacy of broflanilide (VECTRON T500), a new meta-diamide insecticide, for indoor residual spraying against pyrethroid-resistant malaria vectors.. https://doi.org/10.1101/2020.11.06.367961

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