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bioRxiv · 10.1101/2020.10.22.351155

Maternal transmission of a paramutant phenotype requires intact DNMT2 functions in the male germline

Yu, T.·Xie, Y.·Tang, C.·Wang, Y.·Yuan, S.·Zheng, H.·Yan, W.
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Abstract

INTRODUCTION Abstract INTRODUCTION Results DISCUSSION METHODS AND MATERIALS SUPPLEMENTARY MATERIALS Funding Author contributions Competing interests Data and materials availability Supplemental Figures REFERENCES DNA methylation, as a major epigenetic modification in the genome of higher eukaryotes, is catalyzed by DNA methyltransferase enzymes (DNMTs) by addition of a methyl group to the 5th carbon position of cytosine, resulting 5-methylcytosine (5mC) (1, 2). DNMT1 is the most abundant DNA methyltransferase in mammalian cells, and mainly methylate hemi-methylated CpG dinucleotides as a maintenance methyltransferase, although DNMT1 has also been ...

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Yu, T., Xie, Y., Tang, C., Wang, Y., Yuan, S., Zheng, H., Yan, W.. 2020-10-22. Maternal transmission of a paramutant phenotype requires intact DNMT2 functions in the male germline. https://doi.org/10.1101/2020.10.22.351155

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