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bioRxiv · 10.1101/2020.10.21.346635

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury

Pluchino, S.·Hamel, R.·Peruzzotti-Jametti, L.·Ridley, K.·Testa, V.·Yu, B.·Rowitch, D.·Marioni, J.
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Abstract

Innate immune responses following spinal cord injury (SCI) participate in early secondary pathogenesis and wound healing events. Here, we used time-resolved scRNAseq to map transcriptional profiles of SC tissue-resident and infiltrating myeloid cells post-SCI. Our work identifies a novel subpopulation of Fabp5+ inflammatory myeloid cells, comprising both resident and infiltrating cells and displaying a delayed cytotoxic profile at the lesion epicentre, which may serve as a target for future therapeutics.

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Pluchino, S., Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J.. 2020-10-21. Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury. https://doi.org/10.1101/2020.10.21.346635

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