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bioRxiv · 10.1101/2020.10.13.338038

The emergence of inter-clade hybrid SARS-CoV-2 lineages revealed by 2D nucleotide variation mapping

Wang, H.-L.
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Abstract

I performed whole-genome sequencing on SARS-CoV-2 collected from COVID-19 samples at Mayo Clinic Rochester in mid-April, 2020, generated 85 consensus genome sequences and compared them to other genome sequences collected worldwide. I proposed a novel illustrating method using a 2D map to display populations of co-occurring nucleotide variants for intra- and inter-viral clades. This method is highly advantageous for the new era of "big-data" when high-throughput sequencing is becoming readily available. Using this method, I revealed the emergence of inter-clade hybrid SARS-CoV-2 lineages that are potentially caused by homologous genetic recombination.

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Wang, H.-L.. 2020-10-14. The emergence of inter-clade hybrid SARS-CoV-2 lineages revealed by 2D nucleotide variation mapping. https://doi.org/10.1101/2020.10.13.338038

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