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bioRxiv · 10.1101/2020.10.06.328591

Natural variation of the cardiac transcriptome in humans

Domitrovic, T.·Moreira, M. H.·Carneiro, R. L.·Ribeiro-Alves, M.·Palhano, F.
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Abstract

We investigated the gene-expression variation among humans by analyzing previously published mRNA-seq and ribosome footprint profiling (RP) of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals.

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Domitrovic, T., Moreira, M. H., Carneiro, R. L., Ribeiro-Alves, M., Palhano, F.. 2020-10-08. Natural variation of the cardiac transcriptome in humans. https://doi.org/10.1101/2020.10.06.328591

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