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bioRxiv · 10.1101/2020.09.14.296806

Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception

Vilella Mitjana, F.·Wang, W.·Moreno Gimeno, I.·Quake, S.·Simon, C.
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Abstract

We investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.

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Vilella Mitjana, F., Wang, W., Moreno Gimeno, I., Quake, S., Simon, C.. 2020-09-14. Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception. https://doi.org/10.1101/2020.09.14.296806

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