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bioRxiv · 10.1101/2020.08.31.274167

A novel humanized mouse model to study mucosal HIV-1 transmission and prevention

Vanshylla, K.·Held, K.·Eser, T.·Gruell, H.·Jain, K.·Weiland, D.·Muench, J.·Gruettner, B.·Geldmacher, C.·Klein, F.
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Abstract

Humanized mice have been critical for HIV-1 research, but are inefficient at mucosal HIV-1 transmission. We present a fetal tissue-independent model called CD34T+ with enhanced human leukocyte levels in the blood and improved T cell homing to the gut-associated lymphoid tissue. CD34T+ mice are highly permissive to intra-rectal HIV-1 infection, which can be prevented by infusion of broadly neutralizing antibodies. Therefore, CD34T+ mice provide a novel platform for mucosal HIV-1 transmission and prevention studies.

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Vanshylla, K., Held, K., Eser, T., Gruell, H., Jain, K., Weiland, D., Muench, J., Gruettner, B., Geldmacher, C., Klein, F.. 2020-08-31. A novel humanized mouse model to study mucosal HIV-1 transmission and prevention. https://doi.org/10.1101/2020.08.31.274167

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