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bioRxiv · 10.1101/2020.08.26.267724

Epitopes targeted by T cells in convalescent COVID-19 patients

Quadeer, A. A.·Ahmed, S. F.·McKay, M. R.
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Abstract

Knowledge of the epitopes of SARS-CoV-2 that are targeted by T cells in convalescent patients is important for understanding T cell immunity against COVID-19. This information can aid the design, development and assessment of COVID-19 vaccines, and inform novel diagnostic technologies. Here we provide a unified description and meta-analysis of emerging data of SARS-CoV-2 T cell epitopes compiled from 15 independent studies of cohorts of convalescent COVID-19 patients. Our analysis demonstrates the broad diversity of T cell epitopes that have been collectively recorded for SARS-CoV-2, while also identifying a selected set of immunoprevalent epitopes that induced consistent T cell responses in multiple cohorts and in a large fraction of tested patients. The landscape of SARS-CoV-2 T cell epitopes that we describe can help guide future immunological studies, including those related to vaccines and diagnostics. A web-based platform has been developed to help complement these efforts.

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Quadeer, A. A., Ahmed, S. F., McKay, M. R.. 2020-08-26. Epitopes targeted by T cells in convalescent COVID-19 patients. https://doi.org/10.1101/2020.08.26.267724

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