Distinct cortical systems reinstate the content and context of episodic memories

Kragel, J. E.; Ezzyat, Y.; Lega, B. C.; Sperlin, M. R.; Worrell, G. A.; Gross, R. E.; Jobst, B. C.; Sheth, S. A.; Zaghloul, K. A.; Stein, J. M.; Kahana, M. J.

doi:10.1101/2020.08.20.248567

bioRxiv · 10.1101/2020.08.20.248567

Distinct cortical systems reinstate the content and context of episodic memories

Kragel, J. E.·Ezzyat, Y.·Lega, B. C.·Sperlin, M. R.·Worrell, G. A.·Gross, R. E.·Jobst, B. C.·Sheth, S. A.·Zaghloul, K. A.·Stein, J. M.·Kahana, M. J.

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Abstract

Episodic recall depends upon the reinstatement of cortical activity present during the formation of a memory. We identified dissociable cortical networks via functional connectivity that uniquely reinstated semantic content and temporal context of previously studied stimuli during free recall. Network-specific reinstatement predicted the temporal and semantic organization of recall sequences, demonstrating how specialized cortical systems enable the human brain to target specific memories.

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Kragel, J. E., Ezzyat, Y., Lega, B. C., Sperlin, M. R., Worrell, G. A., Gross, R. E., Jobst, B. C., Sheth, S. A., Zaghloul, K. A., Stein, J. M., Kahana, M. J.. 2020-08-24. Distinct cortical systems reinstate the content and context of episodic memories. https://doi.org/10.1101/2020.08.20.248567

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