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bioRxiv · 10.1101/2020.08.18.256206

Spontaneous activity competes externally evoked response in sensory cortex

Karvat, G.·Alyahyay, M.·Diester, I.
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Abstract

The functional role of spontaneous brain activity, especially in relation to external events, is a longstanding key question in neuroscience. Intrinsic and externally-evoked activities were suggested to be anticorrelated, yet inferring an antagonistic mechanism between them remains a challenge. Here, we used beta-band (15-30 Hz) power as a proxy of spontaneous activity in the rat somatosensory cortex during a detection task. Beta-power anticorrelated with sensory-evoked-responses, and high rates of spontaneously occurring beta-bursts predicted reduced detection. By applying a burst-rate detection algorithm in real-time and trial-by-trial stimulus-intensity adjustment, this influence could be counterbalanced. Mechanistically, bursts in all bands indicated transient synchronization of cell assemblies, but only beta-bursts were followed by a reduction in firing-rate. Our findings reveal that spontaneous beta-bursts reflect a dynamic state that competes with external stimuli.

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Karvat, G., Alyahyay, M., Diester, I.. 2020-08-18. Spontaneous activity competes externally evoked response in sensory cortex. https://doi.org/10.1101/2020.08.18.256206

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