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bioRxiv · 10.1101/2020.08.10.245514

Discovery and biosynthesis of clostyrylpyrones from the obligate an-aerobe Clostridium roseum

Li, J. S.·Du, Y.·Gu, D.·Cai, W.·Green, A.·Ng, S.·Leung, A.·Zhang, W.
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Abstract

Anaerobic bacteria are a promising new source for natural product discovery. Examination of extracts from the obligate anaerobe Clostridium roseum led to discovery of a new family of natural products, the clostyrylpyrones. The polyketide synthase-based biosynthetic mechanism of clostyrylpyrones is further proposed based on bioinformatic, gene knockout, biochemical analysis and heterologous expression studies. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=109 SRC="FIGDIR/small/245514v2_ufig1.gif" ALT="Figure 1"> View larger version (43K): org.highwire.dtl.DTLVardef@1f24265org.highwire.dtl.DTLVardef@1e51bd7org.highwire.dtl.DTLVardef@86c761org.highwire.dtl.DTLVardef@8bd052_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Li, J. S., Du, Y., Gu, D., Cai, W., Green, A., Ng, S., Leung, A., Zhang, W.. 2020-08-11. Discovery and biosynthesis of clostyrylpyrones from the obligate an-aerobe Clostridium roseum. https://doi.org/10.1101/2020.08.10.245514

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