Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

Qu, J.-X.; Cai, Z.; Liu, Y.; Duan, X.; Han, S.; Zhu, Y.; Jiang, Z.; Zhang, Y.; Zhuo, C.; Liu, L.; Yang, L.

doi:10.1101/2020.08.05.238998

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bioRxiv · 10.1101/2020.08.05.238998

Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

Qu, J.-X.·Cai, Z.·Liu, Y.·Duan, X.·Han, S.·Zhu, Y.·Jiang, Z.·Zhang, Y.·Zhuo, C.·Liu, L.·Yang, L.

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Abstract

This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems.

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Qu, J.-X., Cai, Z., Liu, Y., Duan, X., Han, S., Zhu, Y., Jiang, Z., Zhang, Y., Zhuo, C., Liu, L., Yang, L.. 2020-08-06. Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer. https://doi.org/10.1101/2020.08.05.238998

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