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bioRxiv · 10.1101/2020.07.29.227454

Signatures of neutral evolution in exponentially growing tumors: a theoretical perspective

Tung, H.-R.·Durrett, R.
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Abstract

We investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are {lambda}0 < {lambda}1 then the site frequency spectrum is c/f where = {lambda}0/{lambda}1. This is due to the advantageous mutations that produce the founders of the type 1 population. Mutations within the growing type 0 and type 1 populations follow the 1/f law. Our results show that neutral evolution can be distinguished from the two-type model using the site frequency spectrum.

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Tung, H.-R., Durrett, R.. 2020-07-30. Signatures of neutral evolution in exponentially growing tumors: a theoretical perspective. https://doi.org/10.1101/2020.07.29.227454

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