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bioRxiv · 10.1101/2020.07.28.225755

Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart

Lopez, G.·Nicolas, A.·Roman, G.·Godinez, R.·Castro, M. A.
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Abstract

With an aperiodic, self-similar distribution of two-dimensional arrangement of atrial cells, it is possible to simulate such phenomena as Fibrillation, Fluttering, and a sequence of Fibrillation-Fluttering. The topology of a network of cells may facilitate the initiation and development of arrhythmias such as Fluttering and Fibrillation. Using a GPU parallel architecture, two basic cell topologies were considered in this simulation, an aperiodic, fractal distribution of connections among 462 cells, and a chessboard-like geometry of 60x60 and 600x600 cells. With a complex set of initial conditions, it is possible to produce tissue behavior that may be identified with arrhythmias. Finally, we found several sets of initial conditions that show how a mesh of cells may exhibit Fibrillation that evolves into Fluttering.

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Lopez, G., Nicolas, A., Roman, G., Godinez, R., Castro, M. A.. 2020-07-29. Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart. https://doi.org/10.1101/2020.07.28.225755

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