Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine

Wu, J.-J.; Chen, Y.-X.; Li, Y.-M.

doi:10.1101/2020.07.24.217570

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bioRxiv · 10.1101/2020.07.24.217570

Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine

Wu, J.-J.·Chen, Y.-X.·Li, Y.-M.

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Abstract

A novel STING agonist CDGSF unilaterally modified with phosphorothioate and fluorine was synthesized. CDGSF displayed better STING activity over dithio CDG. Immunization of SARS-CoV-2 Spike protein with CDGSF as an adjuvant elicited an exceptional high antibody titer and a robust T cell response, which were better than the group using aluminium hydroxide as a adjuvant. These results highlighted the adjuvant potential of STING agonist in SARS-CoV-2 vaccine preparation for the first time.

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Wu, J.-J., Chen, Y.-X., Li, Y.-M.. 2020-07-24. Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine. https://doi.org/10.1101/2020.07.24.217570

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