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bioRxiv · 10.1101/2020.07.21.068882

The architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography

Abstract

Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. In the proximal region of the centriole, nine microtubule triplets attach to each other via A-C linkers and encircle a central cartwheel structure, which directs the early events of centriole assembly. While the crucial role of the proximal region in centriole biogenesis has been well documented in many species, its native architecture and evolutionary conservation remain relatively unexplored. Here, using cryo-electron tomography of centrioles from four evolutionarily distant species, including humans, we report on the architectural diversity of the centriolar proximal cartwheel-bearing region. Our work reveals that the cartwheel central hub, previously reported to have an 8.5 nm periodicity in Trichonympha, is constructed from a stack of paired rings with an average periodicity of [~]4 nm. In all four examined species, cartwheel inner densities are found inside the hubs ring-pairs. In both Paramecium and Chlamydomonas, the repeating structural unit of the cartwheel has a periodicity of 25 nm and consists of three ring-pairs with 6 radial spokes emanating and merging into a single bundle that connects to the triplet microtubule via the pinhead. Finally, we identified that the cartwheel is indirectly connected to the A-C linker through a flexible triplet-base structure extending from the pinhead. Together, our work provides unprecedented evolutionary insights into the architecture of the centriole proximal region, which underlies centriole biogenesis.

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BibTeXRIS

Klena, N., Le Guennec, M., Tassin, A.-M., van den Hoek, H., Erdmann, P. S., Schaffer, M., Geimer, S., Aeschlimann, G., Kovacik, L., Goldie, K. N., Stahlberg, H., Engel, B. D., Hamel, V., Guichard, P.. 2020-07-22. The architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography. https://doi.org/10.1101/2020.07.21.068882

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