Association of educational attainment polygenic score with school grades in individuals with and without psychiatric disorders.

Rajagopal, V. M.; Trabjerg, B. B.; Grove, J.; Horsdal, H. T.; Petersen, L. V.; Bulik, C.; Bybjerg-Grauholm, J.; Baekvad-Hansen, M.; Hougaard, D. M.; Mors, O.; Nordentoft, M.; Werge, T.; iPSYCH-Broad Consortium,; Mortensen, P. B.; Agerbo, E.; Borglum, A. D.; Demontis, D.

doi:10.1101/2020.07.15.203661

bioRxiv · 10.1101/2020.07.15.203661

Association of educational attainment polygenic score with school grades in individuals with and without psychiatric disorders.

Rajagopal, V. M.·Trabjerg, B. B.·Grove, J.·Horsdal, H. T.·Petersen, L. V.·Bulik, C.·Bybjerg-Grauholm, J.·Baekvad-Hansen, M.·Hougaard, D. M.·Mors, O.·Nordentoft, M.·Werge, T.·iPSYCH-Broad Consortium,·Mortensen, P. B.·Agerbo, E.·Borglum, A. D.·Demontis, D.

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Abstract

Suboptimal school performance is often seen in children with psychiatric disorders and is influenced by both genetics and the environment. Educational attainment polygenic score (EA-PGS) has been shown to significantly predict school performance in the general population. Here we analyze the association of EA-PGS with school performance in 18,495 children with and 12,487, without one or more of six psychiatric disorders and show that variance explained in the school performance by the EA-PGS is substantially lower in children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Accounting for parents socioeconomic status obliterated the variance difference between ADHD-but not ASD-and controls. Given that a large proportion of the prediction performance of EA-PGS originate from family environment, our findings hint that family environmental influences on school performance might differ between ADHD and controls; studying the same further will open new avenues to improve the school performance of children with ADHD.

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Rajagopal, V. M., Trabjerg, B. B., Grove, J., Horsdal, H. T., Petersen, L. V., Bulik, C., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, M., Werge, T., iPSYCH-Broad Consortium,, Mortensen, P. B., Agerbo, E., Borglum, A. D., Demontis, D.. 2020-07-15. Association of educational attainment polygenic score with school grades in individuals with and without psychiatric disorders.. https://doi.org/10.1101/2020.07.15.203661

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