IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.

Laliotis, G. I.; Chavdoula, E.; Paraskevopoulou, M. D.; Kaba, A.; La Ferlita, A.; Anastas, V.; Orlacchio, A.; Taraslia, V.; Vlachos, I.; Capece, M.; Hatzigeorgiou, A.; Palmieri, D. I.; Alaimo, S.; Tsatsanis, C.; Sehgal, L.; Carbone, D. P.; Coppola, V.; Tsichlis, P. N.

doi:10.1101/2020.07.14.195297

bioRxiv · 10.1101/2020.07.14.195297

IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.

Laliotis, G. I.·Chavdoula, E.·Paraskevopoulou, M. D.·Kaba, A.·La Ferlita, A.·Anastas, V.·Orlacchio, A.·Taraslia, V.·Vlachos, I.·Capece, M.·Hatzigeorgiou, A.·Palmieri, D. I.·Alaimo, S.·Tsatsanis, C.·Sehgal, L.·Carbone, D. P.·Coppola, V.·Tsichlis, P. N.

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Abstract

The authors have withdrawn their manuscript. While attempting to reproduce the data on the alternative splicing of exon 2 of U2AF2, they observed that the proposed splicing mechanism could not give rise to a functional U2AF2 protein. In addition, they observed evidence of manipulation in the electropherogram of the splicing junction between exons 1 and 3 and in the primary data on which this electropherogram was based, which were deposited in Mendeley by the first author. These observations raise questions on the integrity of the reported results. In light of this information, the authors have no confidence in the key findings of the paper, and therefore, do not wish it to be cited. If you have any questions, please contact the corresponding author.

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Laliotis, G. I., Chavdoula, E., Paraskevopoulou, M. D., Kaba, A., La Ferlita, A., Anastas, V., Orlacchio, A., Taraslia, V., Vlachos, I., Capece, M., Hatzigeorgiou, A., Palmieri, D. I., Alaimo, S., Tsatsanis, C., Sehgal, L., Carbone, D. P., Coppola, V., Tsichlis, P. N.. 2020-07-15. IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.. https://doi.org/10.1101/2020.07.14.195297

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