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bioRxiv · 10.1101/2020.07.13.200923

An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization

Pages, S.·Chenouard, N.·Chereau, R.·Kouskoff, V.·Gambino, F.·Holtmaat, A.
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Abstract

The organization of sensory maps in the cerebral cortex depends on experience, which drives homeostatic and long-term synaptic plasticity of cortico-cortical circuits. In the mouse primary somatosensory cortex (S1) afferents from the higher-order, posterior medial thalamic nucleus (POm) gate synaptic plasticity in layer (L) 2/3 pyramidal neurons via disinhibition and the production of dendritic plateau potentials. Here we address whether these thalamocortically mediated responses play a role in whisker map plasticity in S1. We find that trimming all but two whiskers causes a partial fusion of the representations of the two spared whiskers, concomitantly with an increase in the occurrence of POm-driven, N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials. Blocking the plateau potentials restores the archetypical organization of the sensory map. Our results reveal a novel mechanism for experience-dependent cortical map plasticity in which higher-order thalamocortically mediated plateau potentials facilitate the fusion of normally segregated cortical representations.

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Pages, S., Chenouard, N., Chereau, R., Kouskoff, V., Gambino, F., Holtmaat, A.. 2020-07-14. An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization. https://doi.org/10.1101/2020.07.13.200923

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