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bioRxiv · 10.1101/2020.07.03.186148

Alcohol Dependence Differentially Alters Orbitofrontal Cortex Representations of Inferred Decision-Making and Outcomes

Cazares, C.·Schreiner, D. C.·Gremel, C. M.
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Abstract

Alcohol dependence results in long-lasting deficits in decision-making and behavioral control. Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for value contributions to decision-making as well as action control, and alcohol dependence induces long-lasting changes to OFC function that persist into protracted withdrawal. However, it is unclear which contributing OFC computations are disrupted in alcohol dependence. Here, we combined a well-validated mouse model of alcohol dependence with in vivo extracellular recordings during an instrumental task in which lever press duration serves as the contingency, and lever pressing is sensitive to outcome devaluation. We found prior alcohol dependence did not impair use of duration contingency control but did reduce sensitivity to outcome devaluation. Further, alcohol dependence increased OFC activity associated with lever-pressing but decreased OFC activity during outcome-related epochs. Hence, alcohol dependence induces a long-lasting disruption to OFC function such that activity associated with actions is enhanced, but OFC activity in relation to outcomes is diminished. This has important implications for hypotheses regarding compulsive and habitual phenotypes observed in addiction.

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Cazares, C., Schreiner, D. C., Gremel, C. M.. 2020-07-04. Alcohol Dependence Differentially Alters Orbitofrontal Cortex Representations of Inferred Decision-Making and Outcomes. https://doi.org/10.1101/2020.07.03.186148

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