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bioRxiv · 10.1101/2020.07.01.181644

Recalled parental bonding interacts with oxytocin receptor gene polymorphism in modulating anxiety and avoidance in adult relationships

Cataldo, I.·Bonassi, A.·Lepri, B.·Foo, J. N.·Setoh, P.·Esposito, G.
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Abstract

Early interactions with significant individuals affect social experience throughout the course of a lifetime, as a repeated and prolonged perception of different levels of care, independence or control influences the modulation of emotional regulatory processes. As many factors play a role in shaping the expectations and features of social interaction, in this study we consider the influence of parental bonding and genetic allelic variation of oxytocin receptor gene polymorphism (rs53576) over levels of experienced anxiety and avoidance in 313 young adults belonging to two different cultural contexts, namely Italy and Singapore. Results highlight a major effect of maternal characteristics, care and overprotection, with differences between the two cultural groups. Additionally, the interaction between rs53576 and maternal overprotection suggest different environmental susceptibility in the Italian sample and the Singaporean one. Implication in clinical work and future steps are described in the conclusion.

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Cataldo, I., Bonassi, A., Lepri, B., Foo, J. N., Setoh, P., Esposito, G.. 2020-07-02. Recalled parental bonding interacts with oxytocin receptor gene polymorphism in modulating anxiety and avoidance in adult relationships. https://doi.org/10.1101/2020.07.01.181644

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