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bioRxiv · 10.1101/2020.06.29.175877

Global profiling of the crotonylome in Small Cell Lung Cancer

Guo, Z.·Gu, M.·Huang, J.·Zhou, P.-K.·Ma, T.
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Abstract

Small cell lung cancer is a deadly neuroendocrine lung cancer subtype, which harbors the driver mutations of RB1 and TP53 as well as EP300/CREBBP. Since CREBBP/p300 are two prominent crotonyl-CoA transferases responsible for the global crotonylation in cells, here we investigated the crotonylome in SCLC tissues compared with normal lung tissues through TMT labeling coupled with LC-MS/MS and found unique patterns of protein crotonylation in SCLC related pathways.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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Guo, Z., Gu, M., Huang, J., Zhou, P.-K., Ma, T.. 2020-06-29. Global profiling of the crotonylome in Small Cell Lung Cancer. https://doi.org/10.1101/2020.06.29.175877

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