Personalized vagino-cervical microbiome dynamics after oral probiotics

Chen, C.; Hao, L.; Tian, L.; Song, L.; Zhang, X.; Jie, Z.; Tong, X.; Xiao, L.; tao, z.; Jin, X.; Xu, X.; Yang, H.; Wang, J.; Kristiansen, K.; Jia, H.

doi:10.1101/2020.06.16.155929

bioRxiv · 10.1101/2020.06.16.155929

Personalized vagino-cervical microbiome dynamics after oral probiotics

Chen, C.·Hao, L.·Tian, L.·Song, L.·Zhang, X.·Jie, Z.·Tong, X.·Xiao, L.·tao, z.·Jin, X.·Xu, X.·Yang, H.·Wang, J.·Kristiansen, K.·Jia, H.

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Abstract

The vaginal microbiota is presumably much simpler than the gut microbiome, and oral probiotics appear as a promising means to modulate its homeostasis in the general population. Here, 60 women were followed for over a year before, during and after a probiotic containing Lactobacillus rhamnosus GR-1 and L. reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support colonization of the probiotics to the vagino-cervical microbiome, yet the microbiome was stable in those dominated by Lactobacilli and some individuals have likely benefited from this medication-free intervention.

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Chen, C., Hao, L., Tian, L., Song, L., Zhang, X., Jie, Z., Tong, X., Xiao, L., tao, z., Jin, X., Xu, X., Yang, H., Wang, J., Kristiansen, K., Jia, H.. 2020-06-17. Personalized vagino-cervical microbiome dynamics after oral probiotics. https://doi.org/10.1101/2020.06.16.155929

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