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bioRxiv · 10.1101/2020.06.16.154674

MOCCASIN: A method for correcting for known and unknown confounders in RNA splicing analysis

Slaff, B.·Radens, C. M.·Jewell, P.·Jha, A.·Lahens, N.·Grant, G. R.·Thomas-Tikhonenko, A.·Lynch, K. W.·Barash, Y.
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Abstract

While the effects of confounders on gene expression analysis have been extensively studied there is a lack of equivalent analysis and tools for RNA splicing analysis. Here we assess the effect of confounders in two large public RNA-Seq datasets (TARGET, ENCODE), develop a new method, MOCCASIN, to correct the effect of both known and unknown confounders on RNA splicing quantification, and demonstrate MOCCASINs effectiveness on both synthetic and real data.

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Slaff, B., Radens, C. M., Jewell, P., Jha, A., Lahens, N., Grant, G. R., Thomas-Tikhonenko, A., Lynch, K. W., Barash, Y.. 2020-06-17. MOCCASIN: A method for correcting for known and unknown confounders in RNA splicing analysis. https://doi.org/10.1101/2020.06.16.154674

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