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bioRxiv · 10.1101/2020.06.15.134403

AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND ACE2, THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASE

Bickler, S. W.·Cauvi, D. M.·Fisch, K. M.·Prieto, J. M.·Gaidry, A. D.·Thangarajah, H.·Lazar, D.·Ignacio, R.·Gerstmann, D. R.·Ryan, A. F.·Bickler, P. E.·De Maio, A.
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Abstract

Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. Older age was associated with increased expression of PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels.

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Bickler, S. W., Cauvi, D. M., Fisch, K. M., Prieto, J. M., Gaidry, A. D., Thangarajah, H., Lazar, D., Ignacio, R., Gerstmann, D. R., Ryan, A. F., Bickler, P. E., De Maio, A.. 2020-06-16. AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND ACE2, THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASE. https://doi.org/10.1101/2020.06.15.134403

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