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bioRxiv · 10.1101/2020.06.11.147116

Bilateral but not unilateral subthalamic stimulation promotes apathy: a translational study in rodents and Parkinson's disease patients

Vachez, Y.·Bahout, M.·Magnard, R.·David, P.-M.·Carcenac, C.·Robert, G.·Savasta, M.·Carnicella, S.·Vérin, M.·Boulet, S.
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Abstract

Apathy, depression, and anxiety represent the main neuropsychiatric symptoms of Parkinsons disease (PD). How subthalamic nucleus deep brain stimulation (STN-DBS) influences these symptoms, especially apathy, is a controversial topic. The present translational study investigates and compares the effect of bilateral or unilateral STN-DBS on this neuropsychiatric triad, combining a pre-clinical approach in rodents and a clinical follow-up of patients with PD. While depression and anxiety related behaviors remain unchanged, bilateral but not unilateral STN-DBS consistently induces apathy in patients and a reward seeking deficit in rodents. Together, these data substantiate the claim that STN-DBS may induce apathy by itself and suggest that bilateral but not the unilateral stimulation might be a critical factor.

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Vachez, Y., Bahout, M., Magnard, R., David, P.-M., Carcenac, C., Robert, G., Savasta, M., Carnicella, S., Vérin, M., Boulet, S.. 2020-06-12. Bilateral but not unilateral subthalamic stimulation promotes apathy: a translational study in rodents and Parkinson's disease patients. https://doi.org/10.1101/2020.06.11.147116

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