Search bioRxiv⌕ Search

bioRxiv · 10.1101/2020.06.10.143925

Disentangling principled and opportunistic motives for reacting to injustice: A genetically-informed exploration of justice sensitivity

Abstract

Moral judgments may be driven by both principled and opportunistic motivations. Being morally principled is to consistently adhere to a single set of rules about morality and justice. Opportunistic morality rather involves selectively enforcing rules when they are beneficial to ones interests. These two kinds of motivations sometimes pull in the same direction, other times not. Prior studies on moral motivations have mostly focused on principled morality. Opportunistic morality, along with its phenotypic and genetic correlates, remains largely unexamined. Here, utilizing a sample from the Norwegian Twin Registry, consisting of 312 monozygotic-and 298 dizygotic twin pairs (N = 1220), we measure peoples propensity to react to injustice as victims, observers, beneficiaries, and perpetrators of injustice, using the Justice Sensitivity scale. Our genetically informative sample allows a biometric modeling approach that provides increased stringency in inferring latent psychological traits. We find evidence for two substantially heritable traits explaining correlations between Justice Sensitivity facets, which we interpret as a principled justice sensitivity (h2 = .45) leading to increased sensitivity to injustices of all categories, and an opportunistic justice sensitivity (h2 = .69) associated with increased victim sensitivity and a decreased propensity to feel guilt from being a perpetrator. These heritable justice traits share a genetic substrate with broad strategies for cooperation (as measured by altruism and trust) and for selectively benefitting oneself over the adaptive interests of others (as measured by social dominance orientation and support for monopolizing territory and resources), and differ genetically and phenotypically from Big Five personality traits.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Eftedal, N. H., Kleppesto, T. H., Czajkowski, N. O., Sheehy-Skeffington, J., Roysamb, E., Vassend, O., Ystrom, E., Thomsen, L.. 2020-06-10. Disentangling principled and opportunistic motives for reacting to injustice: A genetically-informed exploration of justice sensitivity. https://doi.org/10.1101/2020.06.10.143925

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related preprints

Integrated exome-transcriptome analysis of a schizophrenia case with an exceptionally low polygenic risk score

Schizophrenia liability reflects both common polygenic variation and rarer variants of larger effect. We investigated a post-mortem schizophrenia case (SZ07) with a schizophrenia polygenic risk score below the first percentile among ancestry-matched cases, asking whether individual-level genomic and transcriptomic analyses could help identify potentially novel schizophrenia-relevant variants. We used exome analysis with multiple variant-prediction tools to generate a panel of variants and corresponding candidate genes potentially implicated in the pathological process in SZ07. The prioritised variants were then assessed using RNA sequencing of three cortical regions. Of these, only an IZUMO4 splice-acceptor variant showed direct RNA-level support. Beyond variant-specific analyses, we characterised broader transcriptomic abnormalities in the SZ07 brain. Pathway analysis of gene-level expression deviations implicated innate immune processes, calcium signalling, synaptic biology, and axon remodelling. Notably, compared with conventional single-sample biological pathway analysis, the analysis we used showed only a weak association with neuronal specificity, suggesting their reduced sensitivity to the main axis of variation related to cellular composition in bulk brain tissue gene expression data. Although the candidate genes showed no significant pathway-level convergence, the broader transcriptomic profile revealed coherent biological alterations largely compatible with the documented history of cerebrovascular disease in SZ07. These results demonstrate how the integration of exome and transcriptome data at the individual level enables the formulation and constraint of hypotheses regarding patient-specific genetic features and their molecular consequences, while highlighting important limitations related to tissue composition, comorbidity, and the choice of reference cohort.

genetics↗

A genetic screen to identify host factors required for commensal bacterial adherence to the gut epithelia

Bacterial adherence to gut epithelial cells likely involves host genetic components. We isolated a gut commensal bacterium, Lelliottia jeotgali, that can robustly colonize C. elegans through attachment to intestinal epithelial cells. Here, we developed a novel screen in C. elegans to identify host genes required for microbiome bacterial colonization. Using transgenic L. jeotgali strain expressing tdTomato, we conducted forward genetic screens in C. elegans to select for mutants that completely lost colonization. We identified multiple allelic mutations in five different C. elegans genes, termed knockout of Lelliottia adherence (kola) mutants, with a near complete loss of adherence. Each of kola-1-5 is uncharacterized and predicted to encode for a secreted or membrane-bound protein. We also identified gly-5, a GalNAc transferase that initiates O-linked glycosylation. Overall, we describe the first C. elegans screen to identify host factors that control microbiome bacterial colonization in the gut.

genetics↗

Male-specific genome sequences for non-invasive sex identification in Nishikigoi (Cyprinus carpio)

Nishikigoi, ornamental cultivars of the common carp (Cyprinus carpio), are economically valuable aquaculture teleosts in which mature females command significantly higher market prices due to superior body conformation and coloration. Consequently, early and non-invasive sex identification is highly desirable for commercial breeding. Although sex determination in common carp follows an XX/XY system, sex-chromosome-specific markers and field-applicable diagnostic methods for Nishikigoi have remained limited. In this study, we conducted sequence-based bulked segregant analysis using whole-genome shotgun sequencing of female and male pools in Kohaku, a representative Nishikigoi lineage. We identified male-specific candidate contigs and successfully developed PCR-based male-specific markers. Validation across multiple Nishikigoi varieties and wild common carp demonstrated that primary primer pairs achieved high diagnostic accuracy. Comparative genomic analysis revealed that these candidate contigs mapped to the genomic region on chromosome 25B containing the male-determining gene Pangu, with the primary marker located in immediate physical proximity to the gene. To enable field diagnostics, we combined non-invasive epidermal mucus DNA extraction, loop-mediated isothermal amplification (LAMP), and chromatography-printed array strip (C-PAS) technology, establishing a rapid on-site detection workflow. Overall, this study provides highly reliable PCR markers associated with the sex-determination locus and establishes a non-invasive, field-applicable diagnostic platform to streamline commercial Nishikigoi breeding and sex-selected stock management.

genetics↗