Hippocampal and striatal responses during motor learning are modulated byprefrontal cortex stimulation

Gann, M. A.; King, B. R.; Dolfen, N.; Veldman, M. P.; Chan, K. L.; Puts, N. A. J.; Edden, R. A. E.; Davare, M.; Swinnen, S. P.; Mantini, D.; Robertson, E. M.; Albouy, G.

doi:10.1101/2020.06.05.136531

bioRxiv · 10.1101/2020.06.05.136531

Hippocampal and striatal responses during motor learning are modulated byprefrontal cortex stimulation

Gann, M. A.·King, B. R.·Dolfen, N.·Veldman, M. P.·Chan, K. L.·Puts, N. A. J.·Edden, R. A. E.·Davare, M.·Swinnen, S. P.·Mantini, D.·Robertson, E. M.·Albouy, G.

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Abstract

While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof- of-concept study employed a comprehensive multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether individually-tailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and striatum during motor learning. Our results indicate that stimulation influenced task-related connectivity patterns within hippocampo-frontal and striatal networks. Stimulation also altered the relationship between the levels of gamma-aminobutyric acid (GABA) in the stimulated prefrontal cortex and learning-related changes in both activity and connectivity in fronto-striato-hippocampal networks. This study provides the first experimental evidence that brain stimulation can alter motor learning-related functional responses in the striatum and hippocampus.

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Gann, M. A., King, B. R., Dolfen, N., Veldman, M. P., Chan, K. L., Puts, N. A. J., Edden, R. A. E., Davare, M., Swinnen, S. P., Mantini, D., Robertson, E. M., Albouy, G.. 2020-06-06. Hippocampal and striatal responses during motor learning are modulated byprefrontal cortex stimulation. https://doi.org/10.1101/2020.06.05.136531

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